Here is a list of 25 top arts and science colleges in Tamil Nadu, based on various ranking lists and publications:

1. Loyola College, Chennai
2. Presidency College, Chennai
3. Ethiraj College for Women, Chennai
4. Stella Maris College, Chennai
5. Lady Doak College, Madurai
6. M.O.P. Vaishnav College for Women, Chennai
7. Women's Christian College, Chennai
8. Bishop Heber College, Tiruchirappalli
9. Fatima College, Madurai
10. V.O. Chidambaram College, Tuticorin
11. Nirmala College for Women, Coimbatore
12. Queen Mary's College, Chennai
13. Holy Cross College, Tiruchirappalli
14. Thiagarajar College, Madurai
15. PSGR Krishnammal College for Women, Coimbatore
16. The New College, Chennai
17. Srimath Sivagnana Balaya Swamigal Arts and Science College, Thanjavur
18. Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore
19. Thangal Kunju Musaliar College of Arts and Science, Kollam
20. Sathyabama Institute of Science and Technology, Chennai
21. Government Arts College, Coimbatore
22. Dr. Ambedkar Government Arts College, Chennai
23. Arignar Anna Government Arts College, Kanchipuram
24. Kongunadu Arts and Science College, Coimbatore
25. Tamil Nadu National Law School, Tiruchirappalli

This list is not exhaustive and there are many other excellent arts and science colleges in Tamil Nadu that are not included here. It is always a good idea to do your own research and consider a variety of factors, such as the reputation of the college, the quality of the faculty and facilities, and the career prospects of the graduates, when choosing an arts and science college.